Blar i Bergen Open Research Archive på forfatter "Sayaman, Rosalyn W."
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Breast-Specific Molecular Clocks Comprised of ELF5 Expression and Promoter Methylation Identify Individuals Susceptible to Cancer Initiation
Miyano, Masaru; Sayaman, Rosalyn W.; Shalabi, Sundus F.; Senapati, Parijat; Lopez, Jennifer C.; Angarola, Brittany Lynn; Hinz, Stefan; Zirbes, Arrianna; Anczukow, Olga; Yee, Lisa D.; Sedrak, Mina S.; Stampfer, Martha R.; Seewaldt, Victoria; LaBarge, Mark A. (Journal article; Peer reviewed, 2021)A robust breast cancer prevention strategy requires risk assessment biomarkers for early detection. We show that expression of ELF5, a transcription factor critical for normal mammary development, is downregulated in mammary ... -
Changes in Immune Cell Types with Age in Breast are Consistent with a Decline in Immune Surveillance and Increased Immunosuppression
Zirbes, Arrianna; Joseph, Jesuchristopher; Lopez, Jennifer C.; Sayaman, Rosalyn W.; Basam, Mudaser; Seewaldt, Victoria; LaBarge, Mark A. (Journal article; Peer reviewed, 2021)A majority of breast cancers (BC) are age-related and we seek to determine what cellular and molecular changes occur in breast tissue with age that make women more susceptible to cancer initiation. Immune-epithelial cell ... -
Loss of epigenetic suppression of retrotransposons with oncogenic potential in aging mammary luminal epithelial cells
Senapati, Parijat; Miyano, Masaru; Sayaman, Rosalyn W.; Basam, Mudaser; Leung, Amy; LaBarge, Mark; Schones, Dustin E. (Journal article; Peer reviewed, 2023)A primary function of DNA methylation in mammalian genomes is to repress transposable elements (TEs). The widespread methylation loss that is commonly observed in cancer cells results in the loss of epigenetic repression ...